24 BULLETIN 125, U. S. DEPARTMENT OF AGRICULTURE. 



5.19 p. m. the animal was upon her side. Her respiration was labored, but seemed 

 somewhat stronger. Her condition remained very nearly the same until 6 p. m. 

 At 6.30 p. m. she was found dead. 



The autopsy showed that the lungs were slightly congested ; the inner walls of the 

 ileum were congested and the venous blood vessels, generally speaking, were full. 

 It was evident that death had occurred from respiratory paralysis. 



The detailed report of the examination of the internal organs by Dr. Mohler, of the 

 Bureau of Animal Industry, is as follows: 



Kidney (cortex and medulla). Many of the intertubular capillaries in the laby- 

 rinth of the cortex and some Malpighian bodies show a marked distention, but not 

 sufficiently pronounced to be called congestion. There is also a general distention of 

 many of the convoluted tubules and the interstices between the capsule of Bowman 

 and glomeruli with a serous, oedematous exudate. This latter has distended the 

 tubules and compressed the renal epithelial cells, many of which, having become 

 atrophic from pressure, disintegrated and desquamated into the lumen of the tube. 

 While these changes are quite marked in the convoluted tubules, the oedema, des- 

 quamation, and degeneration are absent in the straight portions of the uriniferous 

 tubules of the medulla. The distention of the capillaries, however, is present even 

 in the medulla. No interstitial alterations are present. 



Lung. The characteristic lesion is the intense congestion of the entire organ, the 

 presence of small lobular areas of consolidation, and occasional minute oedematous 

 areas. The larger pulmonary and bronchial vessels are all overdistended, but the 

 interfundibular capillaries show not only overdistention but also diapedesis and 

 outwandering of the leucocytes. No such capillary hemorrhages or poollike accumu- 

 lations of the blood can be seen in this lung as were previously observed in lung 716. 

 The bronchial tubes and the smaller bronchi are unaltered . There is no peribronchitis 

 present, although the bronchial blood vessels have all participated in the distention 

 of the other vessels of the lung. 



Kidney. No acute inflammatory changes present. Evidences of a slight subacute 

 catarrhal nephritis accompanied by mild degenerative changes in the renal cells in 

 the cortical portion of the kidney. No interstitial changes present. 



Liver. Moderate amount of physiological fatty infiltration and a slight congestion of 

 the intralobular capillaries between the liver cords, but no diapedesis of red blood 

 cells or outwandering of leucocytes. The hepatic cells proper show a slight amount 

 of cloudy swelling in isolated lobules. No interstitial changes present. 



Ileum. Shows a slight increase in the adenoid tissue in the niucosa and slight 

 fullness of the blood vessels in the submucosa. There is, however, no congestion, 

 desquamation, or degeneration present. 



SYMPTOMS IN SHEEP OBSERVED AT THE GREYCLIFF STATION. 



The very large number of cases of illness and death observed at 

 the Greycliff station furnished an opportunity for a fairly complete 

 picture of the symptoms produced by Zygadenus poisoning. The 

 symptoms were noted in detail, and the description that follows is 

 drawn from a summarized statement formulated from these notes. 



SALIVATION. 



Generally salivation, or frothing at the mouth, was the first 

 noticeable symptom and continued through the acute period of the 

 illness. It was not invariably present; sometimes it did not appear, 

 especially in the fed cases. It was seen in nearly all the drenched 



