42 BULLETIN 125, U. S. DEPARTMENT OF AGRICULTURE. 



The total time of treatment varied from 4 to 7J hours, and the total 

 quantity of tannic acid given varied from 14 to 16 grams. The 

 doses and intervals were as follows : 



Sheep No. 263: 9 doses, 1 gram each, once in 10 minutes; 2 doses, 1 gram each, once 

 in 30 minutes; 1 dose, 1 gram, in 20 minutes; 2 doses, 1 gram each, once in 30 minutes. 

 Total, 14 grams. 



Sheep No. 216: 7 doses, 2 grams each, once in 30 minutes. Total, 14 grams. 



Sheep No. 267: 5 doses, 1 gram each, once in 10 minutes; 3 doses, 1 gram each, once 

 in 15 minutes; 8 doses, 1 gram each, once in 30 minutes. Total, 16 grams. 



Sheep No. 291: 3 doses, 2 grams each, once in 30 minutes; 1 dose, 2 grams, in 60 

 minutes; 1 dose, 2 grams, in 30 minutes; 2 doses, 2 grams each, once in 60 minutes; 

 1 dose, 2 grams, in 3 hours. Total, 16 grams. 



All these animals recovered and were not as sick as the controls, 

 Nos. 269 and 294. Sheep No. 291 suffered more than the others, 

 but the tannic acid in this case was administered later in the illness, 

 after a course of small doses of Epsom salts had failed to produce 

 any effect. All these animals and the controls were given Zygadenus 

 collected on the same date. The experiments were considered to 

 prove conclusively that repeated doses of tannic acid are beneficial. 



A similar set of experiments was conducted with sodium bicarbon- 

 ate. Seven animals were used, and all, with one exception, were fed 

 Zygadenus material collected on the same date, and in the excep- 

 tional case the material was collected only a few days later. Doses 

 of sodium bicarbonate of 2 and 4 grams were given at intervals vary- 

 ing from 15 to 60 minutes. The total time of treatment was from 

 2J to 5 hours, and the total amount of sodium carbonate given varied 

 from 20 to 48 grams. The doses and intervals were as follows: 



Sheep No. 246: 10 doses, 4 grams each, once in 30 minutes. Total, 40 grams. 



Sheep No. 259: 8 doses, 4 grams each, once in 15 minutes; 4 doses, 4 grams each, 

 once in 30 minutes. Total, 48 grams. 



Sheep No. 264: 6 doses, 4 grams each, once in 60 minutes. Total, 24 grams. 



Sheep No. 292: 10 doses, 4 grams each, once in 30 minutes. Total, 40 grams. 



Sheep No. 293: 4 doses, 4 grams each, once in 30 minutes; 2 doses, 2 grams each, 

 once in 30 minutes. Total, 20 grams. 



Sheep No. 277: 5 doses, 4 grams each, once in 30 minutes; 2 doses, 2 grams each, 

 once in 30 minutes; 1 dose, 2 grams, after 1 hours. Total, 26 grams. 



Sheep No. 240: 3 doses, 8 grams each, once in 60 minutes; 2 doses, 4 grams each, 

 once in 60 minutes. Total, 32 grams. 



Of these animals all recovered but one, No. 264. This sheep re- 

 ceived a total of 24 grams, given at hour intervals. No. 240 also 

 received the remedy at hour intervals and recovered very slowly, 

 being unable to stand on the morning after the poisonous dose had 

 been given. All the other cases, except No. 277, recovered rather 

 quickly. No. 277 was as slow as No. 240, although the doses of 

 sodium bicarbonate were given frequently, and the total amount was 



