44 Thrush 



Potato. Various in different cases. Often floury. 



M ilk. The organism grows very poorly in milk, which is not coagu- 

 lated or fermented. 



Fermentation. The organism utilizes dextrin, mannite, alcohol, 

 lactose, and glycerin without fermentation. 

 Saccharose is destroyed without invertin forma- 

 tion. Glucose, levulose, and maltose are fer- 

 mented very slowly. 



Metabolic Products. In addition to the fer- 

 ments that act upon the sugars, etc., and soften 

 the gelatin, the organism forms alcohol, aldehyd, 

 and acetic acid. 



Pathogenesis. Animals are not known to 

 suffer from spontaneous infection. Grawitz was 

 able to induce thrush in puppies. Stooss in- 

 oculated the scarified vaginas of rabbits with 

 mixed cultures of pyogenic cocci and oidium 

 and obtained thrush plaques. The oidium 

 alone was unable to secure a foothold. Doder- 

 lein, Grosset, and Stooss all succeeded in pro- 

 ducing abscesses, sometimes by subcutaneous 

 injection of the oidium, but usually only when it 

 was combined with pus cocci. In such abscesses 

 the cocci are killed off by phagocytes, and when 

 cultures are made only the oidium grows. 



Plaut points out that this is exactly the reverse 

 Fig. 167. Oidium f i , ./- . i e i 



albicans. Culture in oi what happens in artificial cultures of the two 



gelatin (Hansen). organisms where the cocci outgrow and kill off 

 the oidium. 



Intravenous injection sometimes causes generalized oiidium infec- 

 tion, with colonies of the micro-organism in the kidneys, heart- 

 muscle, peritoneum, liver, spleen, stomach, and intestines. The 

 central nervous system may also show small foci of the infection. 



Immunity. Roger* and Noissettef were able to immunize ani- 

 mals against oidium. 



* " Compt.-rendu de la Societe de Biologic," Paris, 1896. 

 t " These de Paris," 1898. 



