508 



Sleeping Sickness 



micro-organisms and African lethargy, and much interest was being 

 taken in a coccus 'the hypnococcus -that was being studied by 

 Castellani in Uganda. As Castellani was prosecuting the investi- 

 gation of this organism, he chanced to examine the cerebro-spinal 

 fluid of several negroes in Uganda who were suffering from sleeping 

 sickness, and in it found trypanosomes. Even then, though Cas- 

 tellani* realized that these organisms were connected with sleeping 

 sickness, he did not identify them in his mind with the Trypano- 



Fig. 207. Various species of trypanosomes: i, Trypanosoma lewisi of the rat; 

 2, Trypanosoma lewisi, multiplication rosette; 3, Trypanosoma lewisi, small form 

 resulting from the disintegrated of a rosette; 4, Trypanosoma brucei of nagana; 

 5, Trypanosoma equinum of caderas; 6, Trypanosoma gambiense of sleeping sick- 

 ness; 7, Trypanosoma gambiense, undergoing division; 8, Trypanosoma theileri, 

 a harmless trypanosome of cattle; 9, Trypanosoma transvaliense, a variation of 

 T. theileri; 10, Trypanosoma avium, a bird trypanosome; n, Trypanosoma 

 damonia of a tortoise; 12, Trypanosoma solea of the flat fish; 13, Trypanosoma 

 grannlosum of the eel; 14, Trypanosoma rajce of the skate; 15, Trypanosoma rota- 

 torium of frogs; 16, Cryptobiaborreli of the red-eye (a fish). (From Laveran and 

 MesniL) 



* Ibid., May 23, 1903; June 20, 1903. 



