5*5 



Sleeping Sickness 



elusion that the essential lesion is an extensive meningo-encephalitis. 

 To the naked eye, there are scarcely any lesions in sleeping sickness, 

 except the enlargement of the lymph nodes, and even in the nervous 

 system when one looks with care, there is but little to be seen. The 



Fig. 210. Photomicrograph of an eosin-methylene-blue-stained section; 1000 

 diameters. Shows trypanosomes about a small vessel of the cortex of the brain 

 (Wolbach and Binger, in "Jour, of Med. Research"). 



histological examination of the nervous tissues, on the contrary, shows 

 that in both the brain and spinal cord there is proliferation and over- 

 growth of neuroglia cells, especially those connected with the sub- 





felfe 



Fig. 211. Photomicrograph of 

 a Giemsa-stained section; 1000 

 diameters, showing a trypano- 

 some deep in the cortex of the 

 brain (Wolbach and Binger, in 

 ''Jour, of Med. Research"). 



( 



Fig. 2 1 2. Trypanosoma gambiense. 

 Formation of the latent stage and 

 transformation of the latent stage into 

 a trypanosome (after Guiart). 



arachnoid space and the perivascular space, with accumulation and 

 probably proliferation of lymphocytes in the meshwork. Wohlbach 

 and Binger found that the trypanosomes actually escape from the 

 blood-vessels and make their way into the nervous tissue. The 



