Glanders in Human Beings 713 



like those of the tubercle. He first saw epithelioid cells accumulate, 

 followed by the invasion of leukocytes. Tedeschi* was not able to 

 confirm Baumgarten's work, but found the primary change to be 

 necrosis of the affected tissue followed by invasion of leukocytes. 

 The observations of Wrightf are in accord with those of Tede- 

 schi. He first saw a marked degeneration of the tissue, and then 

 an inflammatory exudation, amounting in some cases to actual 

 suppuration. 



Glanders in Human Beings. Human beings are but rarely in- 

 fected. The disease has, however, occurred among those in frequent 



Fig. 290. Farcy affecting the skin of the shoulder (Mohler and Eichhorn, in 

 Twenty-seventh Annual Report of the Bureau of Animal Industry, U. S. De- 

 partment of Agriculture, 1910). 



contact with horses and among bacteriologists. It occurs either 

 in an acute form in which, from whatever primary focus may have 

 been its starting-point, the distribution of micro-organisms may 

 be so rapid as to induce an affection with skin lesions' resembling 

 smallpox and terminating fatally in eight or ten days. 



The chronic form in man is chiefly confined to the nasal and laryn- 

 geal mucosa. It is commonly mistaken for more simple infections, 

 and though it sometimes shows its character by generalizing, it not 

 infrequently recovers. 



Virulence. The organism is said to lose virulence if cultivated 

 for many generations upon artificial media. While this is true, 

 attempts to attenuate fresh cultures by heat, etc., have usually 

 failed. 



* "Zeigler's Beitrage z. path. Anat.," Bd. xin, 1893. 



f " Journal of Experimental Medicine," vol. i, No. 4, p. 577. 



