260 MANUAL OF BACTERIOLOGY. 



on. The cultures live for a considerable time if kept from 

 drying. The gonococcus is not known to produce ure- 

 thritis or conjunctivitis in any of the lower animals. In 

 the peritoneum it may cause suppurative inflammation in 

 mice and guinea-pigs. Reproduction of the disease in 

 man has been effected by experimental inoculation with pure 

 cultures. Besides being the cause of gonorrheal urethritis 

 and infection of the cervix uteri, the gonococcus has been 

 isolated from cases of vaginitis in little girls, and from 

 gonorrheal conjunctivitis. It has been found to be the cause 

 of many cases of pyosalpinx, as well as of gonorrheal proc- 

 titis, arthritis, myocarditis and endocarditis; these condi- 

 tions complicating gonorrhea may also be secondary or 

 mixed infections. 



Bacillus of Soft Chancre (of Ducrey). A small, oval 

 bacillus, usually occurring in chains. It stains with ordinary 

 aniline dyes, but not by Gram's method. It has been culti- 

 vated on human blood-agar (also rabbit blood-agar; the 

 medium deteriorates in a few weeks, Davis). It is culti- 

 vated with difficulty. It is found in the pus of soft chancre 

 or chancroid, usually mixed with other organisms. It has 

 been demonstrated in sections of the ulcers. There seems to 

 be uncertainty with respect to its occurrence in buboes. 

 Ducrey was able to secure it in pure culture by successive 

 inoculations on the human skin. Although this bacillus has 

 not yet been sufficiently studied there seems little doubt that 

 it is the cause of soft chancre. 1 



Bacillus pneumonise (of Friedlander) , or Bacillus nin- 

 cosus capsulatus. 2 A short bacillus with rounded ends, 

 sometimes growing out to a greater length; sometimes 

 occurring in pairs; surrounded by a capsule which is only 

 seen in preparations made from the tissues of infected ani- 



1 Davis, Journal Medical Research, Vol. IX., 1903. 



2 Howard, Philadelphia Medical Journal, February 19, 1898; Curry, 

 Howard, Perkins, Journal Experimental Medicine, Vols. IV. and V. 



