APPENDIX. 



331 



the spore- forming organism. The spores finally break apart 

 and scatter, each destined to invade a red corpuscle and 

 start anew the cycle of development. This cycle may be 

 repeated over and over again, producing a corresponding 

 number of malarial paroxysms. 



FIGS. 96-99. 



o 



Malarial Parasites in Various Stages. (X 1000.) 96, 97 and 98 are 

 tertian parasites ; 98 shows the completion of segmentation. 99 is the 

 crescentic form of the festivo-autumnal parasite. 



Certain full-grown parasites do not complete the cycle of development 

 by sportilation, as described, but, breaking loose from the corpuscle, 

 remain as "extra-cellular" bodies. These are seen chiefly after the 

 paroxysm as large, round, pale bodies containing numerous dancing 

 pigment granules scattered through their substance. They ultimately 

 degenerate and disappear. Some of these extra-cellular forms may be 

 seen to develop long slender processes (flagella), having a very active 

 whip-like motion. Flagella are never observed in perfectly fresh blood 

 but develop only after the blood has been drawn some time, usually 

 fifteen or twenty minutes. 



