INTERLAMELLAR PROLIFERATION OF THE CYST. 629 



shaped appendages, sometimes of microscopic size, which enclosed a 

 cord-like continuation of the parenchyma, and in their thickened end 

 not unfrequently exhibited an independent concentric lamination. 

 Sometimes the granular cord in the interior was interrupted, so that 

 the club-like end then enclosed a small cavity, with a granular mass 

 in the interior. 



I think I am not wrong in interpreting these appendages as stolons 

 or sprouts that is to say, as structures which are equivalent to the 

 previously described buds, although they differ from them in so far as 

 they are continuations not only of the parenchyma, but also of the 

 cuticular wall of the mother-bladder. The ultimate fate is the same 

 in both cases, for the terminal portion of the sprout gradually becomes 

 a daughter-bladder, which not unfrequently 

 even becomes constricted off, and is then 

 associated with the others as an independent 

 structure. Klebs, indeed, is of the opinion 

 that the separate bladders of JEchinococcus 

 multilocularis are still connected with each 

 other, but I have repeatedly convinced my- 

 self of the opposite, although there is no FlGL *te.XtMmeoee** multi- 



. ..,,, loculans. ( x 30.) 



doubt that in many of the bladders, and 



perhaps even in the great majority, there is a continuous connection 



(at least of the cuticle). 



According to all appearance, the bladders of the multilocular 

 Ecliinococcus originate from smaller or larger sacculated masses of 

 parenchyma, which are formed in the manner already described from 

 a folding of the cuticular wall and subsequent marginal growth. I 

 have even occasionally observed in my preparations what looked like 

 interlamellar buds. 1 To this category, perhaps, we ought also to refer 

 small sacs surrounded with a special cuticular layer, which Virchow 

 found in the wall of the larger bladders, and which he regarded as 

 originating in the interior of the above-mentioned stellate network. 

 In general, the multilocular JEchinococcus does not exhibit, in regard 

 to its proliferation, any important differences from the other forms. 

 Yet both Virchow and Schiess assert that in some bladders they have 

 observed several generations encapsuled one within the other. 



The new bladders formed on the external surface remain, how- 

 ever, but rarely within the alveolar space occupied by the mother- 

 bladder. Usually, they very soon press into the adjacent and com- 

 paratively less compact stroma, forming a small special cavity, which 

 always closes after the separation of the buds, and then appears as 



1 Morin also describes these interlamellar buds, and, as we have already mertioned, 

 sometimes even finds heads in them. 



