Anatomical Diagnosis: 



Slight emaciation; no gross lesions; 

 no exudates. Pneumococcus , Type I, was 

 recovered in pure culture from the heart's 

 blood. 



The results of this experiment coincide with tiie find- 

 ings in the previous experiment so far as the heterologous 

 organisms were concerned. There was no decrease after kata- 

 phylaxis in the phagocytic activity against any bacteria except 

 the one responsible for the primary infection. The opsonic 

 curve for pneumococcus, however, is not what we vi/ould expect 

 from the work of Rosenow (22). While there was a decrease in 

 the opsonins for this bacterium after kataphylaxis this de- 

 crease never carried the curve down to the normal level. Here, 

 then, was an animal dying of an infection with its phagocytic 

 defense against the specific organism not only intact but 

 functioning with an efficiency distinctly above tne normal. 

 Whatever the explanation for the defeat of this animal in its 

 struggle against the infection, it does not seem possible to 

 account for it by a rupture in the phagocytic defense. 



Experiment 3. — The experimental animal used in this 

 test was an adult guinea pig - No. 31 - weighing 375 grams. 

 It was injected intravenously with gradually increasing amounts 

 of Pneumococcus, Type I ^ and died 13 days later in a state of 

 extreme cachexia. 



Full details of the experiment, together with the re- 

 sults of the opsonic determinations, are fully set forth in 

 the accompanying tables. 



(15) 



