Anatomical Diagnosis: 



Emaciated; no characteristic typhoid 

 lesions except acute splenic tumor. B. typh o- 

 sus obtained from heart's blood. B. enterid - 

 itis cultivated from heart's blood and gall 

 bladder. 



-t-ataphylaxis in this animal probably occurred on Decem- 

 bei- 26th when there was a marked decline in the opsonic index 

 for the t^rphoid bacilli. The decrease, however, was not suf- 

 ficient to bring the index down to the normal. The phagocytic 

 activity of the blood against B. typhosus was at the time of 

 death more than twice as great as that of a normal control. It 

 is possible, too, that the test gives an inadequate measure of 

 the real opsonic strength of the experimental animal's blood, 

 for Harrison (26) has shown that the lytic action of anti- 

 typhoid serum is so great against the typhoid bacilli as to 

 lower the observed index by dissolving the bacteria before they 

 can be taken up by the leucocytes. That this condition actually 

 existed in this case was demonstrated when the inactivated im- 

 mune serun gave a higher phagocytic index than when the serum 

 was used unheated. 



That the phagocytic cells in this dog, dying of a typhoid 

 infection, rare not functionally impaired is indicated by the 

 following tests: 



(29) 



