resistance. This may perhaps be due to the short pei'iod which 

 elapsed between the fatal inoculation and death. Also there 

 was, as in all preceeding tests, no discoverable change in the 

 indices for any of the non-specific bacteria, either during the 

 course of the infection, or within the agonal period, the time 

 when terminal infections commonly appear. 



The results of these experiments with typhoid infections 

 challenge the validity of Bordet's (28^^ conception that "yield- 

 ing to an infection is primarily due to an inability of the 

 phagocytes to take up the infectin_- agent." 



D. Streptococcus Infections 



Experiment 10. — The experimental animal in this test 

 was a large adult guinea pig - Ko. 23. It was given an initial 

 intravenous injection of 1.5 cc. of a 24 hour broth culture 

 of hemolytic streptococci on November 24, 1920. The inocula- 

 tions were repeated every second day, but were discontinued as 

 soon as it was apparent that a fatal quantity had been given. 

 The guinea pig died sixteen daj'^s after the first injection. 

 During the last six days the infection assumed the most destruc- 

 tive character. Over this period the animal lost 29;^ of its 

 body weight, and throughout the last 24 hours of its life was 

 in a state of astonishing emaciation and weakness. 



The opsonic determinations, together with other data 

 concerning the experiment are recorded in the appended table. 



(33) 



