Anatomical Diagnosis: 



Extren.e emaciation; generalized hemorrhage; 

 purulent exudate in pleural cavities. Strepto- 

 coccus hemoljrticus in pure culture from pleural 

 exudate. Streptococcus hemolyticus and B . pyo - 

 cyaneus cultivated from heart's blood. 



The variations in the opsonic activity against the in- 

 fecting agent in this experiment coincide with the observations 

 of Denj'-s and Leclef (29) in their investigation of streptococcus 

 immunity in rabbits. It is interesting in the present experi- 

 ment that the marked decline in the phagocytic activity against 

 streptococci, after the infection had overcome the general body 

 resistance, parallels almost exactly the curve for loss in 

 weight. There was at no time throughout the experiment any 

 change in opsonic index for any of the non-specific bacteria 

 examined. 



Experiment 11. — In this experiment are presented the 

 results of a study of four cases of fatal spontaneous hemolytic 

 streptococcus infection in cats. The epidemic, of which these 

 cases were a part, appeared in a room containing twenty-five 

 cats, and ran a course so severe that of the whole number only 

 two survived. The onset of the attack was characterized by a 

 nasal discharge and violent sneezing. The cats lost rapidly 

 in weight and died, generally after four or five days. The 

 last 24 hours of the infection was especially severe. The 

 animal was in a state of extreme emaciation and exhaustion, 



(35) 



