of 10 cc. of spinal fluid from a child dead of tubercular 

 meningitis. By December 3 the pig had reached an advanced 

 stage of generalized infection and was extremely weak and 

 emaciated. The pig was sacrificed and a sample of blood ob- 

 tained from the heart for opsonic determinations. 



Anatomical Diagnosis: 



Advanced generalized tuberculosis. 

 Inguinal glands easilj?- palpable; extensive 

 infiltration, haemorrhage, necrosis at site 

 of inoculation. Omentum, studded with 

 tubercles, was rolled into a characteristic- 

 ally snarled mass. There was an extensive 

 distribution of tubercles over the diaphragii 

 and peritoneal wall. Smears from the en- 

 larged glands and omentum revealed the pres- 

 ence of a larp-e number of tubercle bacilli. 



Notwithstanding the destructive changes which the in- 

 fection had produced in this animal, there was no lowered 

 opsonic efficiency for any of the non-specific organisms 

 examined. 



Experiment 16. — The dog studied in this experiment 

 had, when first seen on December 27, already developed charac- 



(43) 



