teristic symptoms of "distemper." There .was a continual nasal 

 discharge associated with frequent sneezing and dyspnea. The 

 animal was emaciated and staggered about when forced to its 

 feet. A small grara-negative bacillus, probably Pasteurella 

 canis . v/as present in enormous numbers in both the nasal secre- 

 tion and blood stream. However, on December 30 the dog began 

 to improve and continued to gain in strength until January 12. 

 On this date it suffered an overwhelming and paralysing col- 

 lapse. After this, the dog was unable to move and lay in a 

 continual stupor. It died o'anuary 14, in a state of wealaiess 

 so profound as at once to set it apart from any other animal 

 observed during this investigation. 



It does not seem possible thao an animal could attain 

 a more defenseless condition than this dog presented during 

 the last 36 hours of its life, and yet throughout this period 

 of extreme physiological depression there was no discoverable 

 rupture in its phagocytic defense. 



Full details of the experiment are set forth in the 

 accompanying table. 



(44) 



