CHANGES IN THE OVARY 



145 



remaining to form a layer within the outer theca in the fully 

 formed corpus luteum. 



On the other hand, several investigators have expressed 

 doubts regarding Sobotta's conclusions, and some have adoptedr~ 

 the theory originally formulated by von Baer that the luteal 

 cells arise from the connective tissue sheath of the follicle, the 

 follicular epithelium being either entirely discharged along with 

 the ovum or else being partially discharged and partially de- 

 generating in situ. Amongst those who have adopted this 

 view are Nagel, 1 who investigated the human corpus luteum ; 



FIG. 34. Early stage in formation of corpus luteum of mouse. (From 



Sobotta.) 

 I, developing luteal cells ; e, germinal epithelium. 



Clark, 2 who contributed an account of the formation of 

 the corpus luteum in the sow and in the human subject ; 

 Doering, 3 who also worked upon the sow, and claimed to 

 have confirmed Clark's account ; and Biihler, 4 Wendeler, 5 



1 Nagel, " Die Weiblichen Geschlechtsorgane," Bardeleben's Handbuchder 

 Anatomic des Menschen, vol. vii., Jena, 1896. " tJber neuere Arbeiten auf clem 

 Gebiete der Anatomic der weiblichen Geschlechtsorgane," Merkel and 

 Bonnet's Ergebnisse d. Anat. u. Entwick, vol. viii., 1899. 



2 Clark, " Ursprung, Wachstum, und Ende des Corpus Luteum," Arch. f. 

 Anat. u. Phys., Anat. Abth., 1898 ; Johns Hopkins Hospital Reports, vol. vii., 1899. 



3 Doering, " Beitrag zur Streitfrage uber die Bildung des Corpus Luteum," 

 Anat. Anz., vol. xvi., 1899. 



4 Buhler, " EntwickelungsstadienMenschlichen Corpora Lutea," Verhand. 

 d. Anat. Gesell., in Pavia, 1900. 



5 Wendeler, Martin's Die Krankheiten der Eierstocke und Nebeneierstocke. 



K 



