28 



ACTIVE IMMUNIZATION 



Technique of Antirabic Vaccination in Man. 



The actual vaccine consists of i c.cm. (2-3 mm. length) of the substance 

 of the spinal cord of a rabbit which has been killed by inoculation with the 

 fixed virus, rubbed up into a fine emulsion with 5 c.cm. of sterile 0.85 NaCl 

 solution. About i to 3 c.cm. of the resulting fluid are injected subcutane- 

 ously into the skin of the abdomen. A cord dried for fourteen days is used 

 for the first injection, emulsions of less attenuated virus are used on suc- 

 ceeding occasions until finally a portion of a spinal cord dried for only three 

 or four days is employed. Pasteur's schemes of the actual doses can thus 

 be drawn up. 



a. For infections at points distant from the central nervous system (mild infections). 



b. For head wounds (severer infections). 



