

TECHNIQUE OF ANTIRABIC VACCINATION 



2 9 



The drawback to this classical method of Pasteur consists in using the 

 virulent material rather late in the course of the inoculations. A more 

 energetic treatment has therefore been advised. There is no added 

 danger in doing this because the virus fixe in contrast to the street virus is not 

 at all or only slightly infectious for man. 



Hogyes in Buda Pesth uses the virus fixe right from the start. He be- 

 gins with marked dilutions (1/10,000) and gradually increases them to 

 i/ioo. The theory underlying this procedure is, that the usual method of 

 attenuation by drying alters the quantity of the virus but not its quality; 

 hence the same result may be obtained by simple dilution. 



Ferran successfully employs the virulent virus in large doses right 

 from the onset of the treatment. Especially in very severe infections, as 

 in bites from wolves, is this procedure justifiable. 



The exact arrangement of doses varies a little at different institutions. 

 In Berlin, it is considered that the virulence of the dried cord is lost on 

 about the eighth day instead of the fourteenth. Hence in the hydro- 

 phobia department of the Berlin Institute for Infectious Diseases, the 

 authorities have adopted the following scheme, which stands midway 

 between Pasteur's classical method and the extreme procedure of Ferran. 



Scheme for treatment of mild infections: 



Scheme for treatment of severe infections: 



