TREATMENT WITH SENSITIZED BACILLI EMULSION 



On close observation of this chart it will be noticed that practically no 

 reactions occurred in spite of the 

 rather rapid increase in the dosage. 

 Slight temperatures were mani- 

 fest only occasionally (o.ooooi 

 c.cm. S. B. E.). Even though 

 the same dose was not repeated on 

 account of the long intervals 

 between the individual injections, 

 no increased reaction appeared 

 after < subsequent inoculation. 

 When o.i c.cm. of S. B. E. pro- 

 duced no reaction, the suscepti- 

 bility to B. E. was tested. Doses 

 of o.oooi B. E. to 0.5 B. E. were 

 administered at short intervals, 

 without any symptoms. Only 

 after i.o c.cm. of B. E. was there 

 a slight increase of temperature 

 with rather marked general mani- 

 festations (headache, pains in 

 the extremities, weakness, etc.), 

 which subsided within twenty- 

 four hours. On repetition of the 

 same dose, no reaction occurred. 



Six days later, when for the 

 third time i c.cm. of B. E. was 

 given there set in a much more 

 marked general disturbance, as 

 evidence of hyper-susceptibility. 

 (See Chart 2.) 



3. Bovine -tuberculin. 



Koch's differentiation between 

 bovine and human tuberculosis 

 led; to the attempt at immuniza- 

 tion of cattle with human tubercle 

 bacilli. (Bovo-vaccine of Beh- 

 ring, and Tauruman of Koch). 



Spengler tried to reverse this 

 use and employ the milder, infec- 

 tious bovine bacilli for the tuberculin therapy in man. He used these 



