244 



CHEMOTHERAPY 



by adding the hydroxide: in both instances the sodium salt of dioxydiamidoarseno- 

 benzol is formed. 



As = As 



fH 2 



ONa ONa 



The toxicity of salvarsan is comparatively mild. The following table of Hata shows 

 this in detail. 



Salvarsan has no effect upon spirochetes in the test-tube. In vivo, however, Hata 

 found a single injection of a relatively small dose sufficient to effect a complete cure in 

 mice infected by the spirillum of relapsing fever. The results are seen from the fol- 

 lowing table. 



CURATIVE EFFECT OF DIOXYDIAMIDOARSENOBENZOL. 



Complete cure obtained after. 



Salvarsan is even more active in hen spirillosis; here Hata found 0.0035 g m - P ro 

 kilogram to be a curative dose. 



Syphilis in rabbits requires o.oi to 0.015 gm. pro kilogram by intravenous injection 

 for curative action. 



After these very favorable results were repeatedly obtained in the lower 

 animals, salvarsan was used in man. A very large number of cases has 

 now been treated and important and definite conclusions have been 

 reached. 



