274 



RESULT OF INJECTIONS OF VACCINES 



antibodies is derived from a study of their behaviour when a 

 patient is inoculated with their specific antigens. If, for instance, 

 a patient with a low index for tuberculosis is inoculated with a 

 small dose of new tuberculin (say y^^ milligramme), consisting 

 of the dead bodies of the tubercle bacilli, a very definite train of 

 phenomena, closely comparable to the results of an injection of diph- 

 theria toxin, is produced. In each case there is an immediate fall 



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FIG. 65. EFFECT OF A SINGLE INJECTION OF TUBERCULIN, SHOWING THE 

 "FALSE RISE." (Wright.) 



of variable duration, followed by a rise to a higher level than the 

 initial one in other words, there is a negative followed by a 

 positive phase. (In some cases there is a sharp " false rise " of 

 short duration, which precedes the negative phase, a phenomenon 

 which, as far as I am aware, has not been found with the un- 

 doubted antibodies.) Now this rise, as has been already pointed 

 out, is to some extent at least a specific one ; an injection of 

 uterculin does not cause a rise in the opsonic index to staphy- 





