PRACTICAL APPLICATIONS 



395 



to B. coli vaccine treatment cures all the symptoms and reduces 

 the pus and bacilli present in the urine to a small fraction of its 

 original amount, but fails to remove them entirely. Other 

 observers have been more fortunate (Wright, Western, Norton, 

 and others), but I believe my experience is the general one, and 

 that complete cures are unusual. There is no doubt, however, 

 that the treatment is the best available, the disease being 

 notoriously resistant to simple methods of treatment. If the 

 injections are made with opsonic control, the dilution method of 



FIG. 71. CHART FROM A SEVERE CASE OF CYSTITIS DUE TO B. COLI. 



The continuous line shows the temperature, the dotted line the amount of 



pus in the urine. 



estimating the index should be used. In default of this, the 

 injections may be given every eight to twelve days, doubling the 

 dose until the upper limit is reached. 



The treatment of inflammatory lesions of other regions (chole- 

 cystitis, persistent sinuses, etc.) appears to be more satisfactory, 

 remarkable cures having been obtained. Butler Harris has 

 obtained good results in endometritis, cervical catarrh, and 

 mucous colitis. In the former disease he gives a small dose a 

 week before and after each menstrual period. 



It is in infections due to B. coli that some of the most striking 



