Capsule of corpuscle 



)F THE SENSES ANd THE COMMON INTEGUMENT 



The end-bulbs of Krause (Fig. 934) are minute cylindrical or oval bodies, consisting of a 

 capsule formed by the expansion of the connective-tissue sheath of a medullated fiber, and 



containing a soft semifluid core in which the axis-cylinder 

 terminates either in a bulbous extremity or in a coiled-up 

 plexiform mass. End-bulbs are found in the conjunctiva 

 of the eye (where they are spheroidal in shape in man, but 

 cylindrical in most other animals), in the mucous mem- 

 brane of the lips and tongue, and in the epineurium of 

 nerve trunks. They are also found in the penis and the 

 clitoris, and have received the name of genital corpuscles; 

 in these situations they have a mulberry-like appearance, 

 being constricted by connective-tissue septa into from two 

 to six knob-like masses. In the synovial membranes of 

 certain joints, e. g., those of the fingers, rounded or oval 

 end-bulbs occur, and are designated articular end-bulbs. 



The tactile corpuscles of Grandry occur in the papillae of 

 the beak and tongue of birds. Each consists of a capsule 

 composed of a very delicate, nucleated membrane, and 

 contains two or more granular, somewhat flattened cells; 

 between these cells the axis-cylinder ends in flattened disks. 

 The Pacinian corpuscles (Fig. 935) are found in the 

 subcutaneous tissue on the nerves of the palm of the hand 

 and sole of the foot and in the genital organs of both sexes; 



they also occur in connection with the nerves of the joints, and in some other situations, as in 

 the mesentery and pancreas of the cat and along the tibia of the rabbit. Each of these cor- 

 puscles is attached to and encloses the termi- 

 nation of a single nerve fiber. The corpuscle, 

 which is perfectly visible to the naked eye 

 (and which can be most easily demonstrated 

 in the mesentery of a cat), consists of a num- 

 ber of lamellse or capsules arranged more or 

 less concentrically around a central clear space, 

 in which the nerve fiber is contained. Each 

 lamella is composed of bundles of fine connec- 

 tive-tissue fibers, and is lined on its inner sur- 

 face by a single layer of flattened epithelioid 

 cells. The central clear space, which is elon- 





Medullated 

 nerve fiber 



FIG. 934. End-bulb of Krause. (Klein.) 



FIG. 935. Pacinian corpuscle, with its system of 

 capsules and central cavity, a. Arterial twig, end- 

 ing in capillaries, which form loops in some of the 

 intercapsular spaces, and one penetrates to the cen- 

 tral capsule, b. The fibrous tissue of the stalk, n. 

 Nerve tube advancing to the central capsule, there 

 losing its white matter, and stretching along the 

 axis to the opposite end, where it ends by a tubercu- 

 lated enlargement. 



FIG. 936. Papilla of the hand, treated with acetic 

 acid. Magnified 350 times. A. Side view of a papilla 

 of the hand. a. Cortical layer, b. Tactile corpuscle, c. 

 Small nerve of the papilla, with neurolemma. d. Its two 

 nervous fibers running with spiral coils around the tactile 

 corpuscle, e. Apparent termination of one of these fibers. 

 B. A tactile papilla seen from above so as to show its 

 transverse section, a. Cortical layer, b. Nerve fiber, c. 

 Outer layer of the tactile body, with nuclei, d. Clear 

 interior substance. 



gated or cylindrical in shape, is filled with a transparent core, in the middle of which the axis- 

 cylinder traverses the space to near its distal extremity, where it ends in one or more small 

 knobs. Todd and Bowman have described minute arteries as entering by the sides of the 

 nerves and forming capillary loops in the intercapsular spaces, and even penetrating into the 

 central space. 



