CHANGES OF THE SUPERFICIAL ENDOTIIELIUM. 67 



the omentum, where we have become acquainted with isolated pseudo- 

 , stomata in the normal state. 



(6.) Chronic Peritonitis. Still more does the condition of limited 

 endothelial proliferation come into view in chronic inflammation. 

 If we tuberculise l a guinea-pig by the well-known method of injecting 

 material of an indurated lymphatic gland into the abdominal cavity, 

 the most instructive appearances result, as regards germination of the 

 endothelium, round and about the stornata, especially on the omentum, 

 on the parietal peritoneum, on the centrum tendineum, and on the 

 mesentery. The process is most intense on the omentum. Here we 

 find, as long as the tuberculous process has not yet advanced very 

 extensively, a very active germination of the endothelium on the 

 knots and cords frequently mentioned, and whose number and size 

 have decidedly increased. Under these circumstances the true 

 stomata can be made out in many cases much easier in fresh prepa- 

 rations and silver-treated objects than in the normal condition. 

 Their number, compared with that of the pseudo-stomata, is de- 

 cidedly smaller. We shall limit ourselves to the smaller lymphatic 

 knots, for on the larger the process of germination of the endo- 

 thelium has already advanced so far that it even comprises the endo- 

 thelium of the thin connective-tissue trabeculae of the neighbourhood, 



I do not think it necessary for understanding the matter that I 

 should once more enumerate all those appearances which indicate 

 an active germination of the endothelium. The germination of the 

 endothelium on the fenestrated portions in the form of small buds 

 consisting of young endothelium, is also a very active one ; here we 

 are able to perceive, on account of the great number of such buds, 

 the presence of a protoplasmic stalk emerging from the matrix, and 

 representing the centre of these little buds. This protoplasmic 

 central stalk corresponds completely to a pseudo-stoma. The 

 germination of young endothelial-looking cells is to be observed on 

 the pseudo-stomata themselves in great numbers, If we trace, in a 

 preparation mounted in serum, a thin cord usually projecting towards 



1 We refer the reader to the detailed account of artificial tuberculosis by Burdon- 

 Sanderson ; in the same place a detailed account is given of the macroscopic conditions of 

 the affected organs. 



F 2 



