CHANGES OF THE SUPERFICIAL ENDOTHELIUM. 71 



diagnosis is rendered more difficult by the abundance of new growth, 

 and by the lymphatics being filled with young cells. The same 

 occurs as regards the germination of the endothelium round the 

 stomata when the guinea-pigs are suffering from chronic inflamma- 

 tion of the peritoneum, whether this be the result of the introduction 

 of solid bodies (pieces of gutta-percha, according to Cohnheim and 

 Frsenkel), or of the injection of pysemic fluids and consequent chronic 

 pyaemia (see Dr. Sanderson's Report, 1872) into the abdominal 

 cavity. 



A fact worth noticing is, that guinea-pigs in which the tuberculi- 

 zation was induced by subcutaneous injection, or by direct injection 

 into the blood-vessels, exhibit a marked difference, viz. whereas in 

 those cases in which the tuberculization has been induced by the 

 peritoneum, and in which, the peritoneum being more advanced in 

 the tubercular process than the internal organs (as the lymphatic 

 glands, spleen, liver, and lungs), the germination of the endothelium 

 round the stomata or pseudo-stomata is the first and chief change to 

 be made out at a time when the tubercular process has made very 

 little progress, one^ does not find this to be the case when the tuber- 

 culization has been induced subcutaneously or by the vessels, for a 

 marked growth of the endothelium round the stomata does not take 

 place until the tuberculosis in general is very advanced. 



The same conditions with which we have become acquainted in 

 the preceding as regards the omentum and centrum tendineum are 

 to be observed on the mesentery. In those cases, where the mesentery 

 exhibits moderately far-advanced tuberculous affection, the growth 

 of the endothelium around the true stomata occurs in a very striking 

 manner. Figs. 9 and 12 are taken from such a mesentery; here, 

 over the greatest part of the mesentery, there could be demonstrated 

 with great ease the stomata vera themselves, as well as the germina- 

 tion of their endothelium. Besides this, the germination of the 

 endothelium round the pseudo-stomata and the budding of young 

 cells from the pseudo-stomata themselves was quite distinct. 



What had been said in reference to the change of the endothelium 

 surrounding true and pseudo-stomata in the guinea-pig, I have found 

 to be also true of the mesentery and 'omentum of monkeys which 



