232 THE SECRETIONS: 



On the application of heat, there was a considerable coagu- 

 lation of albumen, which was tinged brown by hsematin. 

 The specific gravity was 1017'0. 

 The analysis gave : 



Analysis 105. 



Water . ... 948-14 



Solid residue ..... 51-88 



Urea ..... 7'63 



Albumen ..... 15-00 



Globulin . ... 1-00 



Haematin, extractive matter with salts, and haematoglobulin 23-80 



I have in several cases made qualitative examinations of the 

 urine in Bright' s granular degeneration of the kidneys, and have 

 always found it albuminous, usually pale, and of an acid or 

 neutral reaction. The amount of albumen varies exceedingly. 



Rayer, 1 who has long and accurately studied this disease, 

 asserts that, in the acute form of the disorder, the urine is at 

 first discharged scantily, that it is coloured red or brown by 

 the presence of blood, that it has an acid reaction, and has 

 usually a higher specific gravity than normal urine ; when al- 

 lowed to stand, fibrous-looking red flocculi of blood, (fibrin ?) 

 are precipitated which, when examined under the microscope, 

 appear to consist of blood-corpuscles and mucus-granules mixed 

 with epithelium. After some days the urine becomes of a citron- 

 yellow colour, but upon the recurrence of the paroxysms the 

 blood-red tint reappears, and disappears during the remissions. 

 The amount of albumen discharged in twenty-four hours often 

 fluctuates considerably. The amount of the other constituents, 

 with the exception of the urea, does not seem to vary so much 

 from the normal standard in the course of twenty-four hours in 

 acute nephritis albuminosa as in the chronic form of the disease : 

 the amount of urea is often only slightly decreased, and that of 

 uric acid hardly at all, and consequently the specific gravity is 

 not much affected. 



In the chronic form of the disease, Rayer usually found the 

 urine rather acid at the period of its discharge, but sometimes 

 neutral or alkaline; it was always pale, often turbid, and at times 

 had a curdy appearance from the presence of small white flocculi 

 swimming in it, which, under the microscope, appeared as mi- 



1 Maladies des Reins. 



