TUBERCLE. 



479 



An ultimate analysis, after the most careful removal of foreign 

 constituents gave : 



Carbon . . 53-888 -> 



Hydrogen . . 7*112 I which corresponds with the 



Nitrogen . . 17*237 [ formula C 43 H 35 N 6 13 



Oxygen. . . 21-767-' 



Hence tubercle may be regarded as protein 1 (C 48 H 36 N 6 O 14 ), 

 from which five atoms of carbon, one of hydrogen, and one of 

 oxygen have been removed. 



A mass of tubercle deposited in the liver, when examined 

 under the microscope, was found to contain round, irregular, 

 nucleated cells larger than pus-corpuscles, and numerous in- 

 terspersed granules. 



In 1000 parts there were contained : 



Water ..... 



Solid residue .... 



Fat taken up by ether, consisting of olein and 



826-04 

 173-96 



margann 



Alcohol-extract . 



Water-extract with very slight traces of pyin 

 Insoluble organic residue . 

 Fixed salts 



18-63 

 21-75 



8-34 

 120-34 



4-90 



This insoluble portion contained : 



Carbon . . 54-554-, 



Hydrogen . . 7'121 I which corresponds with the 



Nitrogen . . 16-928 | formula C 45 H 36 N 6 13 



Oxygen . 21-397J 



Hence it may be supposed to be derived from protein that 

 has lost three atoms of carbon and one of oxygen. 



In tubercular masses found in the abdominal cavity, resem- 

 bling coagulated albumen, there were found : 



Water .... 893-82 



Solid residue . . . 106-18 



Fat . 25-40 



Casein and alcohol-extract . 12-39 



Pyin and water-extract . 6-19 



Salts . . . 7-43 



Crude tubercular matter . 54-55 



which yielded in three analyses : 



l. 2. 3. 



Carbon . . 55-299 55-069 55-137 



Hydrogen . . 7'098 7-004 6-944 



Nitrogen . . 16-698 16-534 16-476 



Oxygen . . 20-905 21-393 21-443 



.' This is Liebig's formula. 



