SUPPLEMENT 693 



stomach is excluded and the whole quantity introduced is thus 

 enabled to reach the worms in the intestinal canal. Kiichenmeister 1 

 has already recommended combination of santonin with ol. ricini. 

 Lewin, 2 however, states that ol. morrhuae, ol. olivarum, ol. cocos 

 and ol. cinae can also be taken. In prescribing santonin in oily solu- 

 tion Henoch 8 also prefers the combination with ol. ricini. According 

 to Lewin's direction the prescription would run as follows : 



1^; Santonin ... ... ... ... ... O'2 grm. 



Ol. ricini. ... ... ... ... ... 2O'O grm. 



Ol. cinre oelh. ... ... ... ... gtt. iv. 



M.,d.s. 



S., one tablespoonful to be taken two to three times. 



If the patients should manifest a repugnance to castor oil, 

 Starke's ricinus paste may be selected: 



R Santonin ... ... ... ... ... o*2grm. 



Ol. ricini ... ... ... ... ... 2cro grm. 



Ol. cinae seth. ... ... ... ... gtt. iv. 



Sacch. albi. ... ... ... ... q.s. 



Pasta moliis. 



S., to be used fur two days. 



If necessary the first-mentioned mixture might be given in gelatine 

 capsules. Small children should be given 0*025 grm. santonin in 

 warm olive oil slightly sweetened with sugar (a teaspoonful) in the 

 morning ; if in the course of the forenoon specimens of Ascaris 

 escape, a second dose should follow in the afternoon about two 

 hours after the meal. Older children should be given santonin in 

 combination with castor oil or calomel : 



R Santonini ... ... ... ... .... O'Oi to 0*02 to 0*03 grm. 



Calomelan ... ... ... ... ... 0*025 grm. 



Sacch. albi... ... ... ... ... o*5gim. 



M.f.p. D. tal. dos. x. 

 S., one powder about six, seven, and eight o'clock on three consecutive days. 



As santonin causes slight toxic symptoms such as urticaria, 

 vomiting, retention of urine, headache, vertigo, yellow vision 

 (xanthopsia), it is in every case advisable to follow with a laxative to 

 expel the drug from the body as speedily as possible. The urine 

 is coloured yellow from one to two days and assumes a scarlet 

 red colour upon the addition of alkalis ; this, however, soon 

 disappears, while it persists in the case of rhubarb and senna. 



In the place of santonin iodoform in the form of a powder mixed 



1 Kiichenmeister, he. cil. - Lewin, zee Sti'ert, Deutich. ;//<?</. Zeitg.^ 1885. 



3 Henoch, idem. 



