72 PRINCIPLES OF STOCK-BREEDING. 



lias had no appearance of the disease ; the three other 

 children are boys, of whom the eldest, aged fourteen 

 years, and the youngest, aged nine years, suffer from 

 the disease, while the other son, aged eleven years, is 

 free from it. 



" The family of the other daughter consists of 

 three children, the eldest of whom, aged six years, is, 

 as in the former case, a girl, and free from the disease, 

 while the two other children, who are boys, aged re- 

 spectively three years and one year, have the skin very 

 decidedly affected. It is to be noted that the disease, 

 in these grandchildren, has in each case appeared 

 within a few months after birth." * 



A tendency to excessive haemorrhage, from even 

 slight injuries, is well known to be hereditary, and 

 this to such an extent that " in some families scarcely 

 a single male arrives at maturity." In his remarks on 

 the heredity of this diseased condition of the system, 

 Mr. Sedgwick says : " In some of these cases it is re- 

 corded that, while the males alone have suffered from 

 the disease, the females alone have been able to trans- 

 mit it, as in the case of Mr. Appleton, whose daugh- 

 ters conveyed the complaint to his grandsons, and 

 who, in their turn, transmitted it through their daugh- 

 ters to their grandsons ; the males in this family, as in 

 many others similarly affected, never inheriting the 

 disease direct from their fathers, but always through 

 females from their grandfathers, as occurred in my 

 case of ichthyosis." a 



1 British and Foreign Medico- Chirurgical Review, 1861, p. 246. 

 8 Loc. cit., July, 1861, p. 146. In the case of Mr. Appleton, above 

 referred to, references are made to the New England Journal of Medi- 



