SUPPLEMENT. 421 



noured the author with tlieir confidence and 

 correspondence, upon the utility of his Di- 

 rectory, and the great efficacy of his Afedi- 

 cines, but called in his assistance upon cases 

 of the greatest difficultx] and dan^^cr, wliere a 

 strict attention to his instructions lias been 

 attended with the ?rfosf perfect success. 



In a work of so inucli extent, involving 

 such variety, and aiming so nuich at general 

 reformation, perfecti(jn atjirsfwa.^ not, coii/J 

 not, beexpected; constantly increasing prac- 

 tice and experience, with incessant ap[)lica- 

 tion and attention, must perpetfta//^ throw 

 new lights upon many parts of the whole, 

 and render perpetually applicable the com- 

 munication of such remarks as may tend to 

 make complete as possible, a tract, in which 

 the public at large have proved themselves 

 60 immediately interested. 



Thus far by way of apology for introduc- 

 ing, under the appendage of a Suppk?/vent, 

 what became in fact a matter indispensabk^ ; 

 for to its necessitij such a combination of cir- 

 cumstances bear powerful evidence, that it 

 was no longer to be avoided: the /itera^v 



