SUPPLEMENT. 421 



emulation condefcend to inveftigate the origin 

 of difeafe, and comprehend the rational method 

 of cure. This palpable convidlion has arifen 

 from the very great number of noblemen and 

 gentlemen of the firft eminence, who have not 

 only honoured the author with their confidence 

 and correfpondence, upon the utihty of his 

 Diredlory, and the great efficacy of his Me- 

 dicines, but called in his affiftance upon cafes 

 of the greateft difficulty and d^mgevy v/here a 

 ftridl attention to his inftrucflions has been 

 attended with the inojl perfeB fuccefs. 



In a work of fo much extent, involving fuch 

 variety, and aiming fo much at general reform- 

 ation, perfection at firjl was not, could 72oty 

 be expedied; conftantly increaling pradlice and 

 experience, with inceifant appUcation and at- 

 tention, muft perpetual!/ throw new lights 

 upon many parts of the whole, and render per- 

 fedlly applicable the communication of fuch 

 remarks as may tend to make complete as 

 poffible, a trad, in which the public at large 

 have proved themfelves fo immediately inte- 

 refled, 



E e 3 Thus 



