FERMENTATION 



unites with benzole acid by replacing the hydroxyl in 

 the side-chain, thus forming 



C 6 H 6 .CO.NH X 



)CH a 

 CO.OH 



HIPPURIC ACID 



Cinnamic acid, toluene, and other aromatic substances 

 are similarly excreted as hippuric acid when taken 

 internally. 



The reversible action of the kidney ferment is im- 

 portant in hastening the establishment of the equi- 

 librium between benzoic acid and glycocoll. If these 

 two bodies pass through the kidney, a certain amount 

 of hippuric acid is formed ; if hippuric acid itself 

 passes through the kidney, a certain quantity is hy- 

 drolyzed. 



Relation of Reversible Action to Absorption of Fat. 

 "Pancreatic juice is capable of hydrolyzing all the fat 

 of a fatty meal in the period of pancreatic digestion. 

 In the living intestine the .hydrolysis should be com- 

 plete, inasmuch as the removal of the products of the 

 hydrolysis by absorption prevents the establishment 

 of equilibrium. On the other hand, the products of 

 the hydrolysis in their transition through the epithelial 

 cells come in contact with a lipolytic enzyme, the pres- 

 ence of which in these cells has been demonstrated in 

 the above. 



"The lipase now finds itself in contact with only 

 fatty acid and glycerine, and hence in acting catalyti- 

 cally to bring about the chemical equilibrium, it effects 



