ASIATIC CHOLERA AND THE CHOLERA ORGANISM 591 



with Spirillum cholerse asiaticae. It possesses a single polar flagellum, 

 and is actively motile. Culturally it is identical with Vibrio cholerse 

 except for slightly more luxuriant growth and more rapid fluidification 

 of gelatin. It gives the cholera-red reaction in pepton media. 



It is differentiated from the cholera vibrio by its power to produce 

 a rapidly fatal septicemia in pigeons after subcutaneous inoculation of 

 minute quantities. 1 It is much more pathogenic for guinea-pigs than 

 the cholera vibrio. It is not subject to lysis or agglutinated by cholera 

 immune sera. 



Spirillum Massaua. This organism was isolated at Massaua by 

 Pasquale 2 in 1891 from the feces of a clinically doubtful case of cholera. 

 Culturally and morphologically it is much like the true cholera vibrio, 

 but in pathogenicity is closer to Spirillum Metchnikovi, in that small 

 quantities produce septicemia in birds. It possesses four flagella. 

 It does not give a specific serum reaction with cholera immune 

 serum. 



Spirillum of Finkler-Prior. 3 Isolated by Finkler and Prior from the 

 feces of a case of cholera nostras. Morphologically it is like the true 

 cholera spirillum, though slightly larger and less uniformly curved. 

 Culturally it is much like the cholera vibrio, but grows more rapidly 

 and thickly upon the usual media. It does not give the cholera-red 

 reaction, nor does it give specific serum reactions with cholera im- 

 mune serum. 



Spirillum Deneke. 4 A vibrio isolated by Deneke from butter. Much 

 like that of Finkler-Prior. It does not give the cholera-red reaction. 



1 Pfeiffer und Nocht, Zeit. f . Hyg., vii, 1889. 



2 Pasquale, Giorn. med. de r. eserc. ed. R. Marina, Roma, 1891. 



3 Finkler und Prior, Erganz. Hefte, Cent. f. allg. ges. Phys., 1884. 



4 Deneke, Deut. med. Woch., iii, 1885. 



