HYPHOMYCETES 



641 



Asia, and the South Sea Islands. It is characterized by recurrent at- 

 tacks of diarrhea, which are accompanied in many cases by a charac- 

 teristic inflammation of the tongue. It runs a prolonged course, but 

 is frequently fatal. Ashford * has isolated from the tongue and from 

 the stools of 200 patients an organism which he calls Monilia. It 

 occurs at first as a round yeast-like body, which soon has a tendency 

 to form mycelia. It reproduces both by side buds and by terminal 

 conidia. It is isolated on Saboureaud's 4 per cent glucose agar with a 

 reaction of -j- 2 per cent. 



FIG. 150. ASPERGILLUS GLAUCUS. m. Mycelial threads. s. Sterigmata. 

 r. Ascospore. p. Germinating conidium. A. Ascus. (After de Bary.) 



On this medium it forms clean-cut, round, hemispherical, creamy- 

 white, refractive colonies. In gelatin stabs it grows along the line of 

 puncture with fine hair-like lateral shoots. It does not liquefy gelatin. 

 It turns milk alkaline and does not coagulate it. It produces acid and 

 gas on glucose, maltose, levulose, saccharose, and galactose, but does 

 not ferment other sugar media. On passage through laboratory ani- 

 mals (rabbits, guinea-pigs) it produces a systemic mycosis and grad- 

 ually increases in virulence. With these, passage strains, stomatitis, 

 and diarrhea may be produced by feeding. Diarrhea was also pro- 

 duced in a monkey by feeding. The organism loses its virulence on 



1 Ashford, Am. Jour, of Med. Sc., 1915, cl, p. 680, 



