20 DAVID J. DAVIS 



he produced a real whooping-cough in animals by the inoculation 

 of his organism, but these results have never been substantiated. 

 Ritter's animal experiments were not conclusive. Injected into the 

 circulation, his diplococcus produced no effect. Czaplewski and 

 Hensel, and also Zusch, obtained no results in animals with their 

 organism. Koplik reported that intravenous inoculation with his 

 bacillus produced suppurative arthritis, that 5 c.c. of culture inocu- 

 lated into white mice killed in one week, and that the organisms were 

 present in the blood ; but that inoculation of guinea-pigs and rabbits 

 with sputum gave negative results. Vincenzi's results were negative. 

 Elmassian, with his organism, produced death in young guinea-pigs 

 by intraperitoneal inoculation in 24 hours or less, and isolated the 

 bacillus from the fluids and heart's blood; there was marked pha- 

 gocytosis. Intravenous injection into rabbits produced some cache- 

 xia, while pigeons and mice did not react. Manicatide obtained no 

 results by inoculating his bacillus "z" into the nose and trachea of 

 guinea-pigs, cats, dogs, and monkeys. Jochmann and Krause were 

 not able to produce any effect either with sputum or pure cultures of 

 their bacillus, when inoculated into the nasal cavities, throat, or 

 peritoneum of animals. On the other hand, Smit found Jochmann's 

 bacillus pathogenic for young guinea-pigs by peritoneal injections, 

 and that it also produced lameness, general infection, and death in 

 rabbits by intravenous injection. He also produced double-sided 

 conjunctivitis in a rabbit, and obtained the bacillus in the exudate. 

 A distinct reaction occurred in the horse when injections were made 

 with the bacillus for immunizing purposes. Wollstein reports nega- 

 tive results with the influenza-like organism from intraperitoneal 

 and subcutaneous inoculations in white mice, guinea-pigs, and rabbits, 

 and also from a subdural inoculation in a rabbit. 



For comparison with the above results, we may briefly refer to 

 results obtained with Pfeiffer's bacillus. Inoculation experiments 

 with the sputum of influenza patients and with pure cultures of the 

 bacillus upon guinea-pigs, rats, mice, and doves are generally without 

 result. In rabbits and monkeys some symptoms have been produced. 

 Pfeiffer, by injecting the bacilli into the lungs of monkeys, observed 

 symptoms simulating those of influenza, and by intratracheal injec- 

 tion of the bacilli killed a monkey in eight hours. There being no 



