272 EVOLUTION AND DISEASE. 
Leprosy is distinguished anatomically by the forma-_ 
tion of nodules or tubercles in the skin, mucous mem- 
branes and underlying tissues. When the skin is affected 
the hands, feet, and face are most frequently attacked. 
Uy, jas 
Fic, 135.—The face ofa Leper. (After Ziegler.) 
increases and forms a sub-globular, soft, pale-coloured 
prominence, which, when knocked or rubbed, may 
ulcerate. Leprous ulcers are commonest on the inside 
of the nose, on the conjunctiva, and mucous membrane 
of the larynx. When the nodules form on nerve sheaths 
anzsthesia is produced. 
Microscopically, leprosy nodules are found to be made 
