276 SPECIAL HISTOLOGY. 



favour (Beitr., p. 78), is explained by Ins having confounded the 

 peculiar secondary muscular fasciculi in the plagiostomous 

 fishes with the primitive fasciculi of the higher Vertebrata. In 

 the Batrachia, according to Lebert and Remak, in the deve- 

 lopment of the muscles, elongated simple cells, with self-multi- 

 plying nuclei, are found, the contents of which cells undergo a 

 metamorphosis similar to that occurring in the elongated 

 muscular tubules formed of numerous cells, which, according 

 to my observations, also exist in these animals. The contractile 

 part of the muscular fibre, whether it be transversely striped 

 or not, and whether it present fibrils or not, is generally 

 developed from without to within, in the sarcolemma, forming 

 a sort of tube which does not become solid till afterwards ; 

 less frequently it appears as a more solid cord on one side 

 within the muscular fibre. In the former case, the nuclei and 

 the original contents of the formative cells, which often 

 contain a large quantity of fatty matter, are situated in 

 the interior of the embryonic muscular tubule, or between 

 it and the sarcolemma; in the latter always close upon the 

 sarcolemma. 



With respect to the pathological relations of these tissues, 

 the following remarks may be offered: — The substance of the 

 striated muscles is not regenerated, and wounds of muscles 

 heal simply with a tendinous callus. A new formation of them 

 has been noticed by Rokitansky ('Zeitsch. der Wiener/ Aerzte, 

 1849, p. 331), in a case of tumour of the testis in an individual 

 18 years old, and by Virchow ('Yerh. d. Wiirzb/ Ges. I.) in 

 an ovarian tumour. In the latter case, which came under my 

 own observation, there were elongated, fusiform, transversely 

 striated cells, each with a nucleus, similar to those described by 

 Remak in the Tadpole. The state of the elementary 

 parts in hypertrophy of the muscles is uncertain. This con- 

 dition, however, except in the tongue, heart, and certain 

 respiratory muscles (Bardeleben), does not perhaps occur at all; 

 it is at all events extremely rare in the striped muscles. 

 (Romberg, 'Nervenkr./ p. 291, asserts, that such a condition 

 ensues upon long-continued cramps, though it appears to me 

 that this point is not yet sufficiently established.) Equally 

 uncertain, also, is the intimate condition of the muscular 

 elements in the increased development caused by exercise, and 



