6 GASTRIC DIGESTION OF PROTEINS 



exist in the case of a child with gastric fistula. Each time the 

 little patient received food a certain note was sounded on a 

 child 's trumpet ; and after a time, during which this practice 

 was continued, the sound of the trumpet alone, without the 

 actual food, sufficed to cause a flow of gastric secretion. 6 That 

 anger and agitation disturb the appetite is a comparatively 

 common experience of almost every one of us. But Bickel 

 has produced experimental evidence in the same line, by 

 showing that a dog whose equanimity was banished by the 

 irritating sight of a cat not only manifested loss of appetite 

 from anger, but in addition suffered actual cessation of 

 gastric secretion during his period of indignation. 7 The 

 normal taste perceptions are, however, not invariable prece- 

 dents of actual gastric secretion; as Coronedi observed in 

 the course of a "mock meal" experiment the production of 

 an entirely normal gastric juice after having completely 

 anaesthetized the tongue of the experiment animal against 

 sense-perception by painting it with cocaine solution. 8 



Excito-Secretory Stimuli. Mechanical irritants have lit- 

 tle effect in inducing secretion of the gastric juice. However, 

 although Pawlow has denied their influence completely, 

 Arthur Schiff has been able to present evidence that chronic 

 irritation, as from sand particles and similar substances in 

 fluid suspension, may be effective, at least in the sense of in- 

 creasing the secretory flow. 9 In the same connection may 

 be mentioned the fact that in dogs with the pylorus con- 

 stricted by a silver band there occurs a continuous gastric 

 secretion. 10 



In comparing various foodstuffs, the most active secre- 

 tory flow is noted after feeding meat. It has been shown, 

 too, that meat-extractives are particularly influential; but 



8 H. Bogen ( Kinderklinik, Heidelberg), Pfluger's Arch., 117, 150, 1907. 

 7 A. Bickel, Deutsche med. Wochenschr., 1905, 1829. 



G. Coronedi and F. Delitala, Arch, di Fisiol (Festschr. f. Fano), 7, 17; 

 Centralbl. f. d. Ges. Biol., 10, No. 1915, 1910. 



A. Schiff (Inst. R. Paltauf), Zeitschr. f. klin. Med., 61, 220, 1907. 



10 N. B. Foster and A. V. S. Lambert, Proc. Soc. Exper. Biol., 5, 109, 1908. 



