CONTENTS riii 



XVI. FAT METABOLISM. OBESITY 378 



Dependence of Protein Destruction upon the Fat Supply. Im- 

 portance of Lipoids in Nutrition. Parenteral Fat Absorption. 

 Fat Storage in the Body. Deposit of Foreign Fat. Transfor- 

 mation of Fat in the Body. Depot Fat and Cell Fat. Oxidative 

 Function of the Liver in Catabolism of Higher Fatty Acids. 

 Formation of Fat from Sugar. Transformation of Fat into 

 Carbohydrate in the Vegetable Economy. Characteristics of 

 Fat which is Formed de novo from Carbohydrates. Place of 

 Origin of Fat from Carbohydrates. Chemistry of Fat Formation 

 from Sugar. Experiments upon the Disintegration of Fat by 

 Plants. Catabolism of Fatty Acids in the Animal Body. Nature 

 of Obesity. Corpulence and Over-feeding. Antifat Treatments. 

 Fattening. 



XVII. FAT-SPLITTING TISSUE FERMENTS. FAT FORMATION FROM PRO- 

 TEIN. FATTY INFILTRATION AND FATTY DEGENERATION. ORIGIN 



OF MILK-FAT 401 



Fat-Splitting Tissue Ferments. Fat Cleavage in the Blood. 

 Lipase 9f the Leucocytes. Cleavage of Esters in the Tissues. 

 Fat-Splitting Tissue Ferments. Formation of Fat from Protein. 

 Fatty Degeneration and Fatty Infiltration. Fat Phanerosis in 

 Autolysis. Nature of Fat Phanerosis. Formation of Higher 

 Fatty Acids by Microorganisms. Hoffmann's Experiment with 

 Fly-Maggots. Adipocere. Formation of Fat in Ripening of 

 Cheese. Accumulation ot Fat in the Liver in Phosphorus 

 Poisoning. Fatty Degeneration of the Liver. Fatty Infiltration 

 in Other Pathological Conditions. Rosenfeld's Theory. Asso- 

 ciation of Fat Phanerosis in the Phenomena of Fatty Degenera- 

 tion. Fatty Change of the Kidney. Cholesterol-Ester Steatosis. 

 Origin of Milk Fat. Passage of the Fat of the Food into the 

 Milk. Origin of Milk Fat from the Carbohydrates of Food. 

 Lower Fatty Acids in Milk. Sebaceous Glands and Coccygeal 

 Gland. Haptogenic Membranes. 



XVIII. ACETONE BODIES 431 



Acetone Bodies. Relation of Acetone Body Formation to the 

 Corporeal Fat and to that of the Food. Origin of Acetone 

 Bodies from the Lower Fatty Acids with Even Carbon Atom 

 Chain. Possibility of Disintegration of the Longer Fatty Acid 

 Chains into Short Parts. Is 0-oxybutyric Acid a Product of 

 Normal Metabolism? Derivation of Acetone Bodies from Com- 

 pounds with Branched and Cyclical Chains. Carbohydrate 

 Deficiency and Acidosis. Diabetic Coma. Alkaline Treatment 

 of Coma. Antiketogenic Substances. Ammonia Elimination 

 and Acidosis. Interrelations of Acetone Bodies. Determina- 

 tion of Acetone and Diacetic Acid. Quantitative Determina- 

 tion of Oxybutyric Acid. 



XIX. LACTIC ACID. FATE OF BODY-FOREIGN SUBSTANCES IN THE ECONOMY 452 

 Lactic Acid. Quantitative Estimation of Lactic Acid by the 

 Method of Furth and Charnass. Determination of Lactic Acid 

 and 0-oxybutyric Acids Together. Ryffel's Method of Lactic 

 Acid Determination. Postmortem Formation of Lactic Acid. 

 Origin of Lactic Acid from Sugar. Embden's Schema of Sugar 

 Catabolism in the Living Body. Glycerol-Aldehyde as an Inter- 

 mediate Product between Sugar and Lactic Acid. Racemic 

 Acid as an Intermediate Product. Appearance of Lactic Acid 

 in the Urine. Fate of Body-Foreign Materials in the Economy. 

 Decomposition of Fatty Acids and Aliphatic Sidechains. Ca- 

 tabolism of a-aminoacids. Oxidation of Cyclic Nuclei. Reduc- 

 tion Processes in the Economy. Deaminization. Synthetic 



