x CONTENTS 



V. UREA. HIPPURIC ACID EXCRETION OF AMINOACIDS 97 



Urea. Theories of the Formation of Urea in the Living Body. 

 Uraminoacids. Mechanism of Vital Oxidation of Nitrogenous 

 Substances. Ammonium Carbamate. Place of Urea Formation. 

 Exclusion of the Liver. Alkalosis and Acidosis. Arginase. Post- 

 coenal Urea Excretion. Quantitative Estimation of Urea. HJD- 

 puric Acid. Source of Benzqic Acid. Hippuric Acid Elimination 

 in Carnivora and in Man. Hippuric Acid Formation in Herbivora. 

 Behavior of Benzoylated Aminoacids. Synthetic Source of Gly- 

 cocoll from Acetic Acid and Ammonia. Glycocoll and Ornithin as 

 Detoxifying Agents. Quantitative Estimation of Hippuric Acid. 

 Elimination of Aminoacids. Aminoacids in Normal Urine. Elimi- 

 nation of Aminoacids in Disease. Cystinuria and Diaminuria. 

 Quantitative Determination of Aminoacids. 



VI. CREATIN AND CREATININ. OTHER URINARY BASES. OXYPROTEIC 



ACIDS. UROCHROME 122 



Creatin and Creatinin. Quantitative Estimation. Relation 

 Between Creatin and Creatinin. Creatase and Creatinase. Endo- 

 genous and Exogenous Distribution of Creatin-Creatinin Elimina- 

 tion. Relation of Creatin-Creatinin Excretion to Decomposition 

 of Tissue Protein. Muscle as Source of Creatin. Creatin Cleavage 

 from Other Tissues. Test of Hepatic Function. Relation of Crea- 

 tin Metabolism to Processes in the Female Sexual Organs. Pos- 

 sible Origin of Creatin from Arginin. Other Urinary Bases. 

 Methylguanidin, Dimethylguanidin, Vitiatin. Novain. Trime- 

 thylamine. Arnold's Reaction. Urinary Rest-Nitrogen. Oxy- 

 proteic Acids. Fractionation of Oxyproteic Acids. Chemical 

 Position of Urochrome. True Urochrome and Dombrowski's 

 Urochrome. Quantitative Estimation of Oxyproteic Acids. 

 Elimination of Oxyproteic Acids in Normal and Pathological 

 Conditions. Other High-Molecular Residual Substances. 



VII. PHYSIOLOGY OF PURIN METABOLISM 148 



Exogenous and Endogenous Uric Acid Formation. Conversion of 

 Adenin and Guanin into Uric Acid. Guanin Gout in the Hog. 

 Nucleases and Deamidases. Nuclear Disintegration and Urinary 

 Purins. Relation of Purin Metabolism to Muscular Activity. 

 Synthetic Formation of Uric Acid in Birds and Reptiles. Synthetic 

 Purin Formation in Mammals. Allantoin as an End-product of 

 Mammalian Purin Metabolism. Fate of Intermediary Uric Acid 

 in Man. Absence of Uricase in Human Tissues. Fate of Experi- 

 mentally Introduced Purins in Human Metabolism. Decomposi- 

 tion of Purins in the Intestine. Reconstruction of Uric Acid. 

 Methylated Purin Derivatives. Quantitative Estimation of Uric 

 Acid. Wiechowski's Method of Estimating Allantoin. 



VIII. PATHOLOGY OF PURIN METABOLISM 170 



Increase of Uric Acid in the Blood of the Gouty. Question of 

 Increase in the Formation of Uric Acid. Question of Reduction 

 of Uric Acid Decomposition in Gout. Curve of Uric Acid Excre- 

 tion in the Acute Gouty Exacerbations. Delayed Nuclein Ex- 

 change in the Gouty. Gout and Nephritis. Uric Acid Retention. 

 Affinity of Tissues for Uric Acid. Alkali Compounds of Uric Acid. 

 Part Taken by Changes in Alkalescence. Lactam and Lactim 

 Forms of Urates. Nucleinic Acid Combination With Uric Acid. 

 Complex Conditions of Solubility of Uric Acid in Relation to 

 Uric Acid Diathesis. Localization of Uric Acid Depositions. 

 Alkalinity of Tissues in Relation to Uric Acid Deposit. Attempts 

 to Produce Gout Experimentally. Alcoholism. Chronic Plumb- 

 ism. Influence of Excessive Meat Diet. Protracted Feeding of 

 Nucleinic Acid to Dogs. Radium Therapy in Gout. Medicinal 

 Treatment of Gout. The Diet in Gout. 



