PASSAGE OF TRUE PROTEINS 55 



being related to a variation in the degree of swelling. 18 

 Where there coexists with the increased permeability of the 

 intestinal wall a diminished retention by the urinary filter, 

 passage of the foreign protein into the urine can be de- 

 tected, 17 although this does not require special renal 

 permeability as it has long been known that after sub- 

 cutaneous injection of albumoses, albumin and similar sub- 

 stances these substances may at times pass directly into the 

 urine. 18 It goes without saying that such facts are not only 

 of physiological interest but are also of importance in 

 medical practice. For instance, repeated rectal administra- 

 tion of egg albumin may under certain circumstances induce 

 in experiment animals a fatal marasmic condition with 

 anaphylactic phenomena. 19 The well-known attempts of 

 Behring to introduce anti-bodies of various kinds into chil- 

 dren in milk is in direct relation with the question in hand. 

 A full discussion of the subject can be found in a study made 

 by Uff enheimer in the laboratory of Max Gruber. 20 



Borchhardt has been able after feeding to recover in the 

 blood two proteids, recognizable in minute amounts because 

 of their characteristic chemical peculiarities, hemielastin 

 and Bence- Jones albumin (v. Vol. I, of this work, The 

 Chemistry of the Tissues, p. 511 ). 21 And yet Abderhalden 

 has failed to find elastin in the blood, tissues or in the urine 

 after administration of large quantities. 22 



16 E. Mayerhofer and E. Przibram (R. Paltauf's Instit., Vienna), Zeitschr. 

 f. exper. Pathol., 7, 247, 1909; Biochem. Zeitschr., 24, 453, 1910; M. Loeper 

 and Ch. Esmonet, C. R. Soc. de Biol., 64, 445, 1908. 



17 R. Hecke (M. Gruber's Labor., Munich), Miinchener med. Wochenschr., 

 56, 1875, 1909. 



18 H. de Waele and A. J. J. Vandevelde (Ghent), Biochem. Zeitschr., 30, 

 227, 1910. 



L. Petit and J. Minet, C. R. Soc. de Biol., 64, 22, 1908. 



!0 A. Uffenheimer, Arch. f. Hygiene, 55, 140, 1905. 



21 L. Borchhardt, Zeitschr. f. physiol. Chem., 51, 506, 1907; 57, 3C5, 1908; 

 L. Borchhardt and H. Lippmann (Med. Clinic, Konigsberg), Biochem. Zeitschr., 

 25, 6, 1910. 



M E. Abderhalden and Rtiehl, Zeitschr. f. physiol. Chem., 69, 301, 1910. 



