116 UREA. HIPPURIC ACID. AMINO ACIDS 



by a fermentative cleavage of formed hippuric acid, were 

 present in the blood and tissues, they might enter the urine. 53 

 Elimination of Aminoacids in Disease. It is of more 

 interest than the occurrence of small amounts of aminoacids 

 in normal urine to know that in certain pathological con- 

 ditions the excretion of these compounds has been found 

 to be notably increased, as in some of the severe infectious 

 fevers (typhus fever, spotted fever, scarlet fever, pneu- 

 monia and small pox, but not in measles and diphtheria). 54 

 A number of investigators have found increased aminoacid 

 excretion in phosphorus poisoning and acute yellow atrophy 

 of the liver 55 ; a symptom which, as already stated, has 

 been referred to the increased autolysis in the liver peculiar 

 to these conditions. It is noted also in other severe 

 hepatic disturbances, 56 as in poisoning by arsenuretted 

 hydrogen, prussic acid, and in various degenerative 

 changes in the liver, especially cirrhosis, cancer, fatty 

 degeneration and syphilis. It was at one time hoped that 

 the recognition of an increase in aminoacid elimination, 

 especially after purposeful administration of aminoacids 

 (as it were an "alimentary aminuria"), might be utilized in 

 diagnosis as to the functional integrity of the liver. 57 How- 



* G. Embden and A. Marx, Hofmeister's Beitr., 11, 308, 1908 ; A. Bingel 

 (G. Embden's Lab., Frankfurt a. M.), Zeitschr. f. physiol. Chem., 57, 382, 1908; 

 G. Forssner (F. v. Muller's Clinic), ibid., 47, 15, 1906; F. Samuely, ibid., 47, 

 376, 1906; G. Oehler, Biochem. Zeitschr., 21, 48, 1909; A. v. Reusz, Wiener 

 klin. Wochenschr., 22, 158, 1909. 



"v. Jaksch, Zeitschr. f. klin. Med., 47, 1, 1902; 50, 167, 1903; R. Erben, 

 Zeitschr. f. Heilk., 25, 33, 1904; Zeitschr. f. physiol. Chem., 43, 320, 1905; 

 Internat. Beitr. z. Path. u. Ther. d. Ernahrungsstorungen, 2, 252, 1911; A. 

 Primavera (Naples) , Giorn. Internaz. di. Scienze Med., 30 ; abstract in Biochem. 

 Centralbl., 9, No. 880, 1909-10. 



"Literature upon Metabolism in Phosphorus Poisoning, Acute Yellow 

 Atrophy of the Liver, etc.: C. Neuberg, Handb. d. Biochem., 4", 336-337, 1910. 



16 W. Frey (D. Gerhardt's Clinic, Basel), Zeitschr. f. klin. Med., 72, 383, 

 1911; F. Falk and P. Saxl (v. Noorden's Clinic, Vienna), ibid., 73, 131, 1911. 

 N. Masuda (Fr. Kraus' Clinic, Berlin), Zeitschr. f. exper. Pathol., 8, 629, 1911. 



67 K. Glaszner, Zeitschr. f. exper. Pathol., 4, 336, 1907; H. Jastrowitz 

 (Med. Clin., Prague), Arch. f. exper. Pathol., 59, 463, 1908. 



