ELIMINATION OF AMINO ACIDS 117 



ever, it is doubtful at present whether any practical result 

 will be attained. 58 Increase in the aminoacid excretion has 

 also been met in a variety of conditions in which it is not at 

 all evident that we are dealing with disturbances of the 

 hepatic function, as in pregnancy, 59 gout, 60 diabetes, 61 

 leukaemia, 62 and after large hemorrhages. 63 Physiologically 

 the excretion of aminoacids is apparently greater in infants 

 than in grown persons. 64 It is worthy of special attention 

 that an enormous access of aminoacids occurs in the urine of 

 hibernating marmots, with corresponding reduction in the 

 urea. 65 It may well be a time will come when it will be 

 possible to recognize and appreciate a common basis for 

 these heterogeneous facts ; but at the present as far as the 

 author is concerned it is entirely impossible to offer any sug- 

 gestion save by labored and arbitrary theorization. How- 

 ever much the author realizes the importance of hypotheses 

 towards future discovery, he feels that in this case the 

 metabolic chemist has every reason for keeping close to 

 the fundamental facts lest he risk loss of all the footing on 

 which he stands. 



58 Cf. H. Ishihara, Biochem. Zeitschr., 41, 315, 1912 (under direction of 

 O. v. Fiirth). 



W E. C. van Leersum, Biochem. Zeitschr., 11, 121, 1908; C. Holla, 

 Pathologica, 2, 575; abstract in Jahresber. f. Tierchem., 40, 1910; F. Falk and 

 O. Hesky (Clinic of v. Noorden and Schauta, Vienna), Zeitschr. f. klin. Med., 

 71, 261, 1910. 



60 A. Ignatowski (Fr. v. Muller's Clinic, Munich), Zeitschr. f. physiol. 

 Chem., 42, 388, 1904; cf. to the contrary, A. Lipstein (v. Noorden's Clinic, 

 Frankfurt a. M.), Hofmeister's Beitr., 7, 527, 1906. 



"Mies, Munchen. med. Wochenschr., 1894, 671; Nicola, Giorn. d. R. Acad. 

 di Torino, anno 67, Ser. IV, Vol. 10, p. 83, 1904; E. Abderhalden, Zeitschr. f. 

 physiol. Chem., 44, 51, 1905; M. Labbe and H. Bith, C. R. Soc. de Biol., 71, 348, 

 1911. 



"Ignatowski, 1. c. 



68 D. Fuchs (Klausenberg), Zeitschr. f. physiol. Chem., 69, 482, 1910. 



**F. W. S'chultz, Jahresber. f. Kinderheilk., 72, Erganzungsheft, 1910; 

 R. Kadlich and P. Grosser, ibid., 75, 4. 



W K. Nagai (Verworn's Lab., Gottingen), Zeitschr. f. allgem. Physiol., 9, 

 306-334, 1906. 



