OTHER URINARY BASES 133 



OTHER URINARY BASES 



Methylguanidin; Dimethylguanidin ; Vitiatin. Besides 

 creatin and creatinin small quantities of other bases closely 

 related to them may be met at times in the urine. In the Mar- 



burg Physiological Institute methyl guanidin, C(NH)/ , 



NH.CHi 



has been isolated from normal human urine in its relatively 

 insoluble picrolonic acid combination; and in the urine of 

 dogs, after ingestion of meat extract, dimethyl guamdin, 



/NH 2 



C(NH) 



< / 



CHa 



has been found. Vitiatin, with its ascribed 



/NH CH 2 CH 2 N v 



structural formula, C(NH)< 1 \C(NH), (cf. Vol. 



\NH 2 CH 3 / 



NH 2 7 



I of this series, p. 149, Chemistry of the Tissues) has also 

 been met in the urine. 41 



Small quantities of methylpyridin may occur, probably 

 produced from vegetable foods ; pyridin compounds are in- 

 troduced into the body with the nicotine of tobacco smoke 

 and with some of the constituents of coffee. 42 



Novain. Then, too, small quantities of bases may appear 

 in the urine, having a number of methyl groups linked 

 to nitrogen. Kutscher 43 encountered novain (as previously 

 stated in these lectures, Vol. I of this series, p. 151, this 

 substance may be regarded as identical with carnitin, 



CH 3 \ 

 >\ 



CH S N O J ; redact onovain also occurs, re- 



CH,/ CH 2 -CH 2 -CH(OH)-CC/ 



41 F. Kutscher and Lohmann, Zeitschr. f. physiol. Chem., 48, 422, 1906; 

 49, 81, 1906; W. Achelis, ibid., 50, 10, 1906; F. Kutscher, ibid., 51, 457, 1907; 

 R. Engeland, ibid., 57, 49, 1908. 



42 F. Kutscher, 1. c. 



43 F. Kutscher, 1. c. 



