144 OXYPROTEIC ACIDS 



p. 548, Chemistry of the Tissues) far from an ideally exact 

 mode of determination, is still undoubtedly of greater scope 

 than that of Erben, who sought no more than the autoxy- 

 proteic acids (by precipitation of the baryta syrup by 

 mercuric acetate after faint acidulation with acetic acid). 

 This mode of separation must be regarded as largely open 

 to the personal equation, if for no other reason because, as 

 is well known, a part of the mercurial salts of the oxyproteic 

 acids is soluble in a greater surplus of acetic acid. On the 

 other hand it should be acknowledged that it would be a good 

 thing if a modification of the Ginsburg method were worked 

 out by ascertaining the possible admixture of urea and of 

 aminoacids in the fraction of oxyproteic acids, and making 

 correction therefor. 



Elimination of Oxyproteic Acids in Normal and Patho- 

 logical Conditions. With this in view it is best to state only 

 in a provisional way that the quantity of oxyproteic acid in 

 normal urine represents from 3 to 7 per cent, of the total 

 nitrogen in case of adults, 67 and 10 per cent, in infants. 68 



Probably the oxyproteic acids in the "rest nitrogen " of 

 the blood are in greater proportion than they are in the 

 urinary rest nitrogen (it is said that 40 per cent, of the rest 

 nitrogen of the blood serum is here included) ; and it is 

 probable that a part of the haemic oxyproteic acids may 

 be oxidized before they reach the kidney for elimination. 69 



In disease an increased elimination of substances be- 

 longing to the group of oxyproteic acids is usually met in 

 cases in which an increased decomposition of cellular protein 

 is proceeding under the influence of toxic metabolic disturb- 

 ances. This may be expected in phosphorus poisoning, in 



OT W. Ginsburg, 1. c.; W. Gawinski (Instit. of Med. Chem., Lemberg), 

 Zeitschr. f. physiol. Chem., 58, 454, 1909. 



68 S. Simon (Children's Clinic, Univ. Munich), Zeitschr. f. Kinderheilk., 

 2, 1, 1911. 



C8 J. Browinski (Instit. Med. Chem., Lemberg), Zeitschr. f. physiol. Chem., 

 58, 134, 1908; W. Czernecki, Bull, de 1'Acad. de Cracovie, 1910, abst. in 

 Jahresber. f. Tierchem., 40, 189, 1910; cf. also ibid., 39, 820, 1909. 



