HEPATIC FUNCTION IN PANCREATIC DIABETES 253 



pancreas and diabetic and the other a normal animal, and 

 procured thorough commingling of the blood of the two by 

 "crossed carotid transfusion/' there was occasioned in the 

 normal animal only a transitory glycosuria, while in the 

 dog deprived of its pancreas (the experiment being con- 

 tinued a sufficient length of time) the glycosuria disap- 

 peared sometimes but returned after the carotid anasto- 

 mosis had been separated. 15 It is true these findings are 

 neither constant nor entirely convincing, because a low- 

 ering of the renal secretion takes place in connection with 

 them. Forschbach, in Minkowski's Clinic, was more for- 

 tunate in bringing about a blood mixture by an ingenious 

 expedient by which he joined surgically a normal dog and 

 one with pancreatic diabetes into one parabiotic double 

 animal. In this experiment there not only occurred a low- 

 ering and actual disappearance of the glycosuria in case of 

 the animal with pancreatic diabetes, "but the condition of 

 the animals scarcely differed from that of health, and the 

 disappearance of cachexia suggests the idea that the diabetic 

 metabolic fault was attacked at the root." 16 Basically con- 

 sidered one can readily appreciate that in such a pair of 

 animals the pancreas of the normal individual with its in- 

 ternal secretory function is at the disposition of the partner 

 without a pancreas, with the effect that the resultant symp- 

 toms are not necessarily manifested. According to Carlson 

 the internal secretion can apparently pass in pregnancy 

 from the foatus into the blood of the mother. 17 



Formation of Glycogen, Diastasic Power and Formation 

 of Sugar from Carbohydrate- free Material in the Liver in 

 Pancreatic Diabetes. After complete extirpation of the pan- 



15 E. HSdon (Montpellier), C. R. Soc. de Biol., 66, 699, 1909; 67, 792, 1909; 

 68, 341, 1910; 72, 584, 1912; Rev. de MM., 30, 617, 1910. 



"J. Forschbach (Minkowski's Clinic, Greifswald), Deutsch. med. 

 Wochenschr., 1908, 910; Arch. f. exper. Pathol., 60, 131, 1909; cf. also 

 E. Pfliiger, Pfliiger's Arch., 124, 633, 1908. 



17 A. J. Carlson and F. M. Drennan (Chicago), Amer. Jour, of Physiol., 28, 

 391, 1912. 



