METABOLISM IN PANCREATIC DIABETES 259 



constituents. 33 Acidosis may be regarded as a symptom 

 resulting from the destruction of fat (accumulation of 

 /?-oxybutyric acid, diacetic acid and acetone), which is met 

 in pancreatic diabetes as well as in severe human diabetes. 

 Whether these features are entirely and satisfactorily ex- 

 plained on the basis of a lowering of the consumption of 

 sugar (by which the respiratory quotient is diminished) 

 must for the present be left unanswered. 34 



From the above it might be expected that if the con- 

 sumption of sugar in a dog with pancreatic diabetes be 

 raised by physical exertion or exposure to cold, there would 

 result a lowering of the sugar elimination. This is, how- 

 ever, by no means always the case, as shown by the studies 

 of Embden and Liithje. 35 According to Minkowski, in- 

 creased sugar consumption from physical exercise occurs 

 only if some functionable remnant of the pancreatic tissue 

 is present in the subject. After complete exclusion of the 

 pancreatic function it seems that sugar can practically no 

 longer be utilized to defray an increased demand for energy, 

 and at best the latter would only lead to a heightened 

 mobilization of sugar at the expense of the noncarbohydrate 

 stores and therefore (as the mobilized sugar is not oxidized 

 but excreted unchanged) to an increased intensity of the dia- 

 betes. Heat regulation in diabetic animals is correspond- 

 ingly encroached upon apparently. 



J. de Meyer, from a study conducted in Heger's labora- 

 tory in Brussels, would have it that the impermeability of 

 the normal kidney to sugar is related with the internal 

 secretion of the pancreas. If Locke's solution containing 

 about the same proportion of sugar as occurs in the blood 

 be perfused through the fresh (taken from a dog) kidney, 

 sugar passes into the " urine." On adding a small amount 



83 S. la Franca (Naples), Zeitschr. f. exper. Pathol., 6, 1, 1909. 



34 Cf. F. Verzar (Tangl's Lab., Budapesth) , Biochem. Zeitschr., 44, 201, 1912. 



38 H. Liithje, Verb. d. 22. Kongress f. innere Med., Wiesbaden, 1905, 268; 

 G. Embden, H. Liithje and E. Liefmann (Frankfurt, a. M.), Hofmeister's Beitr., 

 10, 265, 1907. 



