260 PANCREATIC DIABETES 



of pancreatic extract to the circulating fluid this "glyco- 

 suria" diminishes appreciably. Other tissue extracts, how- 

 ever, apparently have no specific influence upon the renal 

 permeability. Although these experiments may well permit 

 other interpretations, they seem to deserve further 

 consideration from the standpoint in view. 86 



Partial Extirpation of the Pancreas. Attention should 

 be directed to the recent reports upon partial pancreatic ex- 

 tirpation issued by F. Beach 37 from Durig's laboratory. A 

 long time since Sandmeyer noted an increased output of 

 sugar in dogs after partial removal of the pancreas and 

 administration of a mixed diet of raw horsemeat and raw 

 pancreas; and explained it on the supposition of an aug- 

 mentation in the utilization of the glycogen in the meat 

 by the pancreatic ferment. Beach has shown that this 

 explanation is not correct, but that the raw meat (compared 

 with boiled meat) contains a poison, labile to boiling, which 

 forces up the sugar-excretion in slightly diabetic dogs. 



Antipancreatin Serum. One can readily believe that 

 it has not been possible to entirely resist the temptation 

 of applying the advances in immunology to the great 

 puzzle of pancreatic diabetes. That the blood of animals 

 after extirpation of the pancreas does not contain any 

 "toxine" capable of rendering normal animals diabetic was 

 shown a long time ago by Minkowski and Mering. Accord- 

 ing to J. de Meyer, 38 after injection of extracts of dog pan- 

 creas (heated previously to 70 C.) a supposedly specific 

 antibody (" antipancreatin") appears in the blood serum of 

 rabbits, which not only reduces in vitro the glycolytic power 



88 J. de Meyer (Instit. Solvay, Brussels), Arch. Internat. de Physiol., 8, 

 121, 1909; Recherche sur la signification et la valeur de la secretion interne 

 du Pancreas, Li6ge, Imprimerie H. Vaillant-Carmanne, 1910. 



17 F. Reach (Durig's Lab.), Wiener klin. Wochenschr., 1910, No. 41; 

 Biochem. Zeitschr., 33, 436, 1911; cf. also J. Thiroloix and Jacob, Bull, et 

 Mem. de la Soc. des H6pit. de Paris, 1910, 492. 



88 J. de Meyer, Arch, internat. de Physiol., 7, 317, 1909; 8, 121, 1909; 9, 1, 

 1910; 10, 239, 1910; 11, 131, 1911; Recherche sur la signification, etc., 1. c.; 

 Ann. Instit. Pasteur., 22, 778, 1908. 



