262 PANCREATIC DIABETES 



distinctly reducing the elimination of sugar and of acetone 

 bodies. However, in these as well as in a test undertaken 

 in Minkowski's Clinic, 42 the suggestive fact was manifested 

 that injections of "pancreatic hormone " were often fol- 

 lowed by chills, fever of several days ' duration and malaise. 

 Still later the writer's colleague, C. Schwarz, and the 

 writer 43 were able to show, at least in case of intraperitoneal 

 introduction of pancreatic substance, that this inhibition of 

 adrenin glycosuria is not due to a mysterious antagonism 

 between the " hormones " of the pancreas and of the adrenal 

 glands, but probably is to be explained naturally and easily 

 as depending upon a condition of peritoneal irritation (v. 

 Vol. I of this series, p. 383, Chemistry of the Tissues). This 

 may so affect the secretory ability of the kidneys that 

 elimination of the dissolved constituents of the urine includ- 

 ing sugar, is lowered without the quantity of fluid neces- 

 sarily undergoing any coincident striking diminution. When 

 this fact is considered along with the fact that a great variety 

 of disturbances, perhaps not directly related with the 

 peritoneum (as fever, suppression of urine, introduction of 

 materials with lymphagogue action, etc.), 44 are capable of 

 inhibiting adrenin diabetes, there is apparently not suffi- 

 cient ground here for a pancreatic treatment of diabetes. If 

 in addition the statements of numerous authors 45 are 

 accepted, that injecting and feeding pancreatic substance 

 not only does not arrest the glycosuria in animals with 

 pancreatic diabetes, but in many instances actually intensi- 



42 J. Forschbach (Minkowski's Clinic, Breslau), Deutsch. med. Wochenschr., 

 1909, No. 7. 



43 0. v. Furth and C. Schwarz, Wiener klin. Wochenschr., 1911, No. 4, and 

 Biochem. Zeitschr., 31, 113, 1911. 



44 Cf . the report of Mikulicich upon the inhibition of adrenin diabetes by 

 hirudin (O. Lowi's Lab., Gratz), Arch. f. exper. Pathol., 69, 128, 1912. 



48 Cf. Literature in E. Leschke (Physiol. Instit., Bonn), Arch. f. Anat. u. 

 Physiol., 1910, 401; Mtinchener med. Wochenschr., 1911, No. 26; cf. also 

 N. Tiberti and A. Franchetti (Florence), Lo Sperimentale, 62, 81, 1908; E. L. 

 Scott (Carlson's Lab., Chicago), Amer. Jour, of Physiol., 29, 306, 1912. 



