SUGAR PUNCTURE 297 



sympathetic ganglia, and thence along the splanchnics to the 

 liver. We know, too, that stimulation of the central segment 

 of the vagus and of numerous sensory (particularly visceral) 

 nerves will induce activity of the sugar-centre, and that a 

 great variety of anatomical lesions of the central nervous 

 system (from traumatism, tumors, abscesses, hemorrhages, 

 etc.) may act in the same way. Psychic influences may also 

 induce glycosuria. For example, in cats that have been shut 

 up in a cage and worried for half an hour by a dog enough 

 to have had the latter very manifestly ' ' get on their nerves, ' ' 

 a glycosuria may be observed. 70 



We have no reason for doubting that the mechanism of 

 the sugar puncture involves the liver and includes a process 

 of discharging its glycogen supply; but it is not clearly 

 understood in all points. Only recently two French investi- 

 gators (Wertheimer and Battez) have called attention to the 

 effectiveness of the sugar puncture even in animals which 

 have been placed under the influence of atropin sufficiently 

 to induce a paralysis of all secretory nerves ; and they, there- 

 fore, hold that the supposed connection of the sugar puncture 

 with stimulation of glyco secretory nerves is decidedly ques- 

 tionable. 71 The possibility of a connection between the su- 

 gar puncture and the secretory activity of the adrenals will 

 be taken up fully in the succeeding lecture, in which the re- 

 lation between the ' ' internal secretory glands ' J and carbohy- 

 drate metabolism will be considered. 



Attention should also be called here to the occurrence of 

 glycosuria, according to observations of Minkowski, Bedard, 

 Pfluger and other authors, 72 after a great variety of opera- 

 tive interferences ; it is especially likely to follow irritation 

 of the bowel and peritoneum, according to Pfluger. Zak 

 states that even the mechanical irritation of the intestine 



70 W. B. Cannon, A. T. Strohl and W. S. Wright (Harvard Med. School), 

 Amer. Jour, of Physiol., 29, 280, 1911. 



71 E. Wertheimer and G. Battez, Arch, internat. de Physiol., 9, 140, 363, 

 1910; C. R. Soc. de Biol., 66, 1059, 1909. 



72 Rose, Zak, Gaulthier, Eichler and Silbergleit, Visentini. 



